01

Our vision

BIOACORES S.L. is an innovative technology-based company whose objective is research and experimental development in natural and technical sciences.

The business model of Bioacores S.L. is based on the technology transfer to the industrial sector, focusing its activity in the research and development of extractive processes, outsourcing the stages of industrial production, marketing and sales.

02

Sustainability

The scope of action of Bioacores is clearly inscribed within the fields of waste recovery and the circular economy, respecting the 12 principles of Green Chemistry originally defined by Anastas and Warner in 1988. All of our processes implement recovery and reuse of solvents steps, thus drastically reducing the generation of waste

Below are some texts extracted from different scientific articles:

The Korean Journal of Physiology & Pharmacology

Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. It exerts these effects in various tissues and organs: by suppressing nuclear factor-kappa B signaling in cancer cells, improving insulin signaling in adipose tissues, reducing the expression of markers of cardiac damage in the heart, decreasing inflammation and increasing the level of anti-oxidants in the brain, reducing apoptotic signaling and the level of oxidants in the liver, and reducing atrophy and increasing the expression levels of adenosine monophosphate-activated protein kinase and irisin in skeletal muscles. Moreover, UA can be used as an alternative medicine for the treatment and prevention of cancer, obesity/diabetes, cardiovascular disease, brain disease, liver disease, and muscle wasting (sarcopenia).

Ursolic acid in health and disease. Seo, D. Y.; Lee, S. R.; Heo, J.-W.; No, M.-H.; Rhee, B. D.; Ko, K. S.; Kwak, H.-B.; Han, J. The Korean Journal of Physiology & Pharmacology 2018, 22, 235.

Food Research International

Ursolic acid (UA) is a pentacyclic triterpenoid widely found in herbs, leaves, flowers and fruits; update information on the major natural sources or agro-industrial wastes is presented. Traditional (maceration, Soxhlet and heat reflux) and modern (microwave-, ultrasound-, accelerated solvent- and supercritical fluid) extraction and purification technologies of UA, as well as some patented process, are summarized. The great interest in this bioactive compound is related to the beneficial effects in human health due to antioxidant, antimicrobial, antiinflammatory, hepatoprotective, immunomodulatory, anti-tumor, chemopreventive, cardioprotective, antihyperlipidemic and hypoglycemic activities, and others. UA may augment the resistance of the skin barrier to irritants, prevent dry skin and could be suitable to develop antiaging products. The development of nanocrystals and nanoparticle-based drugs could reduce the side effects of high doses of UA in organisms, and increase its limited solubility and poor bioavailability of UA which limit the potential of this bioactive and the further applications. Commercial patented applications in relation to cosmetical and pharmaceutical uses of UA and its derivatives are surveyed.

Recent developments on the extraction and application of ursolic acid. A review. López-Hortas, L.; Pérez-Larrán, P.; González Muñoz, M. J.; Falqué, E.; Domínguez, H. Food Research International 2017, 103, 130.

ResearchAndMarkets.com

The global ursolic acid market is expected to grow at a compound annual growth rate of 5.02% during the forecast period, reaching a market size of US$5.218 billion in 2027, from US$3.703 billion in 2020. Ursolic acid is a triterpene acid present in many types of plants, such as prunes, hawthorn, thyme, oregano, lavender, blueberries, apples, and others.

This type of acid contains a significant amount of healthy and nourishing properties, including antioxidant, antifungal, antibacterial, and anti-inflammatory properties. Several researches and studies have been carried out to develop ursolic acid extracts and their use in different types of food products, as well as for pharmaceutical purposes.

In 2015, ursolic acid was identified as helping prevent muscle atrophy. A study was conducted in which it was found that ursolic acid supplementation in mice on a high-fat diet improved muscle strength and mass, glucose tolerance, reduced white adipose tissue, and promoted the deposition of brown adipose tissue. This suggests that ursolic acid would be an effective and excellent nutritional requirement to counteract age-related changes in metabolic disorders and body composition. Ursolic acid also has antidepressant properties and improves the formation of ceramides in human skin.

Text from the article: Global Ursolic Acid Market Report 2022: Ursolic Acid Supplements for Fat Reduction and Muscle Mass Gain Driving Growth. ResearchAndMarkets.com

ABOUT THE URSOLIC ACID

Brief summary of properties that have been associated with the ursolic acid in different studies:

Antitumor. Inhibits tumor formation and increase in size when used in conjunction with other drugs.
Anti-inflammatory.
Antioxidant.
Antidiabetic.
Cardiovascular and liver protection.
Inmunomodulator.
Activates blood circulation, promotes the increase in keratinocytes and stimulates scalp health.
Antimicrobial and antiviral effects.
Improves skin eslasticity and thickens the natural collagen.
It transforms the fat stored in the body.
Low toxicity and high efficacy.

Bioacores S.L. has developed a procedure for the extraction of ursolic acid from apple residue, which is the mixture of skin, pulp, stems and seeds that remain after the pressing of the apples for the production of juices or cider. This residue is also known as "apple pomace", or as "magaya" in Asturias. This procedure is protected by the European patent EP3756476A1.

Both the starting biomass, its processing and purification is carried out entirely in Spain, thus ensuring the compliance with the highest GMP quality standards and eliminating risk that involve supply chains that are too long and the dependence on foreign suppliers.

Bioacores is currently developing more methods to recover waste from the food industry. Some of the current lines of research are related to:

Mate Tea (Ilex paraguariensis)

Eucalyptus leaf (Eucalyptus Globulus)

Rosemary (Rosmarinus officinalis)

Sage (Salvia officinalis)

Coffee (Coffea)

Bioacores collaborates with the University of Oviedo in the financing of the project it carries out title: "Glycyrrhetinic acid as a platform for the discovery of new semi-synthetic anti-tumour and antiviral agents." Reference SV-PA-21-AYUD/2021/57460. ERDF funds of the regional plan. Amount granted: 90000 €.

This project is in the development phase. When it is finished, more details will be included in this section.

EUROPEAN UNION
European Regional
Develpment Fund

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Bioacores

Welcome

01

Our vision

02

Sustainability

Below are some texts extracted from different scientific articles:

Brief summary of properties that have been associated with the ursolic acid in different studies:​

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Brief summary of properties that have been associated with the ursolic acid in different studies: