|Biomass||Ursolic Acid Assay|
|Apple peel (Malus domestica)||26%|
|Mate. (Ilex Paraguariensis)||19%|
|Eucalipto (Eucalyptus Globulus)||14%|
|Salvia (Salvia officinalis leaves)||31%|
|Romero (Rosmarinus officinalis)||10%|
Under patent EP19382530.4
Ursolic acid > 95% Under development
Some of the beneficial effects of ursolic acid that have been described include: antioxidant, antimicrobial, anti-inflammatory, hepatoprotective, immunomodulatory, antitumor, chemopreventive, cardioprotective, antihyperlipidemic, hypoglycemic, prevents skin aging.
|Spent coffee||Oil coffee (CAS 84650-00-0)|
Coffee oil is a complex mixture of fatty acids and triglycerides found in coffee beans. Coffee oil has applications in the world of cosmetics, being a very beneficial ingredient in skin creams. In the usual process of preparing coffee by infusion in hot water, these fatty acids are not extracted, since they are insoluble in water. This implies that most of these fatty acids remain in the spent coffee grounds. An ambitious secondary objective of this section is to obtain kaweol and cafestol, two diterpenes with notable biological activity (Yaqi Ren, Chunlan Wang, Jiakun Xu, and Shuaiyu Wang, Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties, Int J Mol Sci 2019 Sep;20(17):4238
There are numerous articles related to the study of ursolic acid. Some examples:
- Recent developments on the extraction and application of ursolic acid. A review. López-Hortas, L.; Pérez-Larrán, P.; González-Muñoz, M. J.; Falque, E.; Dominguez, H. Food Research International 2018, 103, 130-149;;
- Ursolic acid from Apple pomace and traditional plants: a valuable triterpenoid with functional properties. Cargnin, S. T.; Gnoatto, S. B. Food Chemistry 2017, 220, 477;
- Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity. He, X.; Liu, R. H. Journal of Agricultural and food Chemistry 2007, 55, 4366.